The combination of rhetoric and philosophy appeared in the ancient world through Cicero, and revived as an ideal in the Renaissance. By a careful and precise analysis of the views of four major humanists-Petrarch, Salutati, Bruni, and Valla—Professor Seigel seeks to establish that they were first of all professional rhetoricians, completely committed to the relation between philosophy and rhetoric. He then explores the broader problem of the "external history" of humanism, and reopens basic questions about Renaissance culture. He departs from (...) the views held by such scholars as Hans Baron and Lauro Martines and expands the conclusions suggested by Paul Oskar Kristeller. The result is a stimulating, controversial study that rejects some of the claims made for the humanists and indicates achievements and limitations. Originally published in 1968. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

JHI essays on Durkheim, Wittgenstein, Spengler et al and their theories on society versus the individual.

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

ABSTRACTMary Darby Robinson is well known for writing her final volume of poems, the Lyrical Tales, as a direct answer, sometimes poem by poem, to Wordsworth and Coleridge’s 1798 Lyrical Ballads. What has been less studied is how deliberately hybrid in style and allusions her response-poems are in the Tales, especially how prominently they foreground Gothic imagery, theatricality, and hyperbole in poems that also ape the emerging “romantic” mode of the Ballads themselves. Part of that “cheekiness,” I argue, stems from (...) the condemnation of the Gothic that both Wordsworth and especially Coleridge had articulated in print, while also echoing it, albeit in highly modified ways, in their poetry. Most of what Robinson attempts with her hybrid Tales, though, develops the penchant in Gothic for symbolizing deep and unresolved ideological conflicts in Western culture. Her answers to Wordsworth and Coleridge, which I exemplify with selected Robinson Tales, therefore, bring out those very conflicts underlying,... (shrink)

In biscuit conditionals (BCs) such as If you’re hungry, there’s pizza in the fridge, the if clause appears to apply to the illocutionary act performed in uttering the main clause, rather than to its propositional content. Accordingly, previous analyses of BCs have focused on illocutionary acts, and, this, I argue, leads them to yield incorrect paraphrases. I propose, instead, that BCs involve existential quantification over potential literal acts such as assertions, questions, commands, and exclamations, the semantic objects associated with declarative, (...) interrogative, imperative, and exclamative sentences, respectively. Such an existential interpretation of BCs requires only that we add potential literal acts to our inventory of individuals, and it produces reasonable paraphrases in which if has its normal meaning: If you’re hungry,[there’s a (relevant/salient) assertion that] there’s pizza in the fridge. These potential literal act variables are introduced into semantic interpretations and then undergo Existential Closure. Hence, we would expect to see similar interpretations in contexts other than BCs, that is, with other if constructions, with connectives other than if, with potential literal acts other than assertion, and in root sentences. This prediction is borne out, along with the parallel prediction that we cannot quantify over purely illocutionary acts like offers, but only over potential literal acts, those conventionally associated with a particular morphosyntactic shape. (shrink)

The coronavirus disease-2019 (COVID-19) has caused shortages of life-sustaining medical resources, and future waves of the virus may cause further scarcity. The Yale New Haven Health System developed a triage protocol to allocate scarce medical resources during the COVID-19 pandemic, with the primary goal of saving the most lives possible, and a secondary goal of making triage assessments and decisions consistent, transparent, and fair. We outline the process of developing the protocol, summarize the protocol, and discuss the major ethical challenges (...) encountered, along with our answers to the challenges. These challenges include (1) the role of age and chronic comorbidities; (2) evaluating children and pregnant patients; (3) racial, ethnic, and socioeconomic disparities in health; (4) prioritization of healthcare workers; and (5) balancing clinical judgment versus protocolized assessments.We conclude with a review of the limitations of our protocol and the lessons learned. We hope that a robust public discussion of such protocols and the ethical challenges they raise will result in the fairest possible processes, less need for triage, and more lives saved during future waves of the pandemic and similar public health emergencies. (shrink)

This paper effectively inverts the argument of an earlier paper of mine, “The Particularisation of Attributes”, to argue that there are no necessarily particularised and unshareable attributes of the sort that contemporary metaphysics calls tropes. In that earlier paper I distinguished two kinds of attributes, namely, properties and qualities, and argued that if there were tropes they could only be particularised qualities, i.e. particularisations of, say, redness, rather than particularisations of, say, being red. While continuing to hold that there cannot (...) be particularised properties—that the very notion is oxymoronic—I now hold, further, that the supposition of qualities in addition to properties is both ontologically extravagant and conceptually outlandish. Hence there are no qualities, and thus no tropes either. (shrink)

The facts aboutsuch, then, indicate not just thatsuch is a pro-adjective, but also that binding conditions apply broadly to pro-ADJs and pro-CNs, as well as to a wide range of pro-arguments. If this is true, the CN binding process accomplished by rules (40) and (41) might better be expressed in a system that uses a Cooper (1979) store mechanism. In fact, Stump (p. 144) notes that this could easily be done. Meanings of the type of∨ P n could be stored, (...) just as NP meanings are, until an appropriate binding CN phrase was encountered. Binding conditions would simply require that a∨ P n meaning not come out of storage until the derivation had emerged from its governing category. The behavior of the pro-adjectivesuch suggests that an expression of any category, if it is legitimately translatable as a variable, may be a fullfledged proform; many principles and mechanisms described to account for the widely studied pronouns in fact apply to nonargument categories. (shrink)

This volume is a collection of essays by various contributors in honor of the late Laurence Berns, Richard Hammond Elliot Tutor Emeritus at St. John's College, Annapolis. The essays address the literary, political, theological, and philosophical themes of his life's work as a scholar, teacher, and constant companion of the "great books.".

Subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the (...) STN produces similar clinical efficacy.” These discrepancies likely result from methodological differences including targeting preferences, imaging acquisition and the use of brain atlases that do not account for patient-specific anatomic variability. We present a first-in-kind within-patient demonstration of severe mood side effects and minimal motor improvement in a Parkinson’s disease patient following placement of a DBS lead in the limbic/associative territory of the STN who experienced marked improvement in motor benefit and resolution of mood side effects following repositioning the lead within the STN sensorimotor territory. 7 Tesla magnetic resonance imaging data were used to generate a patient-specific anatomical model of the STN with parcellation into distinct functional territories and computational modeling to assess the relative degree of activation of motor, associative and limbic territories. (shrink)

Wissen, so lautet die unausgesprochene Maxime der Humanisten und Polyhistoren der Frühen Neuzeit, kann man nie genug erwerben. Riesige Bibliotheken und Kunstkammern sowie voluminöse Abhandlungen, Geschichtswerke und Enzyklopädien geben noch heute eindrucksvoll Rechenschaft von dieser Leidenschaft. Doch wächst mit der Größe jeder Sammlung auch die Notwendigkeit ihrer Ordnung. Es ist daher kein Zufall, dass ›Ordnung‹ zum Schlüsselbegriff des humanistischen Enzyklopädismus aufgestiegen und zum Gegenstand hartnäckiger Auseinandersetzungen unter den Gelehrten geworden ist. In Steffen Siegels Untersuchung werden die vielfältigen philosophischen Versuche, die (...) Fülle des Wissens systematisch zu ordnen, nicht allein anhand der Überlieferung von Texten rekonstruiert. Im Zentrum dieser reich illustrierten Studie, die bei mittelalterlichen Wissenspraktiken ihren Ausgang nimmt, sich insbesondere den vielschichtigen Bildkulturen des 16. und 17. Jahrhunderts widmet und einen Ausblick auf moderne Visualisierungstechniken bietet, steht die faszinierende Vielfalt jener Bilder, die Ordnungen des Wissens als sichtbare Figuren vor Augen rückten. Die Bedeutung von Schautafeln und Bildallegorien, von wissenschaftlichen Illustrationen und Karten wird, mit Blick auf die Frage nach möglichen Ordnungen des Wissens, in diesem Buch zum ersten Mal übergreifend analysiert. Ein Akzent der Untersuchungen liegt auf der bislang nur wenig erforschten Geschichte des Diagramms in der Frühen Neuzeit. In der Mitte zwischen den Darstellungsmöglichkeiten von Bildern und Texten, standen insbesondere diagrammatische Schemata im Dienst der Konstruktion und der Beglaubigung von Ordnungen des Wissens. Anhand der reichen Tradition frühneuzeitlicher Diagramme lassen sich in hervorragender Weise die Potentiale, aber auch die Probleme eines Zusammenspiels von Wissens-, Ideen- und Mediengeschichte in der Zeit um 1600 ablesen und profilieren. Mit den im Jahr 1587 in Paris publizierten Tableaux legte Montaignes Zeitgenosse Christophe de Savigny eines der erstaunlichsten und reichsten Zeugnisse frühneuzeitlicher Kunst im Dienst einer solchen Wissensgeschichte vor. Das Tafelwerk steht daher im Mittelpunkt der Untersuchungen zu den Figuren enzyklopädischer Wissensordnungen. Erstmals seit seiner Publikation vor über fünfhundert Jahren wird dieses sehr selten gewordene, für die Gelehrtenkultur des 16. Jahrhunderts äußerst repräsentative Werk hier vollständig und in einer farbigen Reproduktion wieder zum Druck gebracht. Die komplexen Strategien, mit Hilfe von Bildern, Diagrammen und Texten für eine bestimmte Wissensordnung zu argumentieren, lassen sich auf diese Weise an einer bedeutenden Quelle der vormodernen Gelehrtengeschichte minutiös nachvollziehen. Die Fülle des Wissens und die Möglichkeiten seiner Ordnung werden dabei als Herausforderungen sichtbar, die in gleicher Weise das Interesse der Kunstgeschichte und der Kulturwissenschaft, der Wissenschafts- und Pädagogikgeschichte und der Philosophie berühren. (shrink)